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2013-05-08 08:51:40
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2013-05-08 08:51:25
FKIP Untirta Gelar Gebyar Hardiknas 2013
2013-05-08 08:50:53
Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

Heme Polymerization Inhibitory Activities of Xanthone from G. parvifolia (Miq) Miq Stem Bark as an Antimilarial
Abstrak

A study had been conducted to isolate, to identify and to test heme polymerization inhibitory activities of G. parvifolia (Miq)Miq stem
bark active compounds with antimalarial properties. UV, IR, RMI 1D (1H NMR and 13C NMR) and RMI 2D (COSY, HMQC and HMBC)
and mass spectra were used for identification. Heme polymerization inhibitory activity assay was conducted in vitro by measuring b-
hematin formation using ELISA reader. The study revealed that active isolates derived from xanthone compounds, 1,3,6-trihydroxy-2-(3-
methylbut-2-enyl)-7-methoxy-8-(3-methylbut-2- enyl)xanthen-9-on. HPIA assay showed that the compounds acted by inhibiting weak
heme polymerization activities.

Penulis : SYAMSUDIN , Prof. Dr. M.Biomed., Apt. [PDF File] didownload : 88 x

Biological activity of Propolis from Jawa
Abstrak
Penulis : SYAMSUDIN , Prof. Dr. M.Biomed., Apt. [PDF File] didownload : 83 x

The effect of Garcinia parvifolia (Miq)Miq extract against liver damage of Plasmodium berghei infected mice
Abstrak

Penulis : SYAMSUDIN , Prof. Dr. M.Biomed., Apt. [PDF File] didownload : 70 x

CYTOTOXIC ACTIVITY OF TRITERPENOID FRACTION OF INDONESIAN PROPOLIS ON HUMAN BREAST CARCINOMA CELL LINES
Abstrak

A study to identify chemical compound of Indonesian propolis and to examine its cytotoxic activity of human breast cancer cells (MCF-7 and T47D) had been conducted. Identification was conducted by using spectrometries of UV, IR, NMR (1H-NMR and 13C-NMR) and mass spectra; while cytotoxic test was conducted with MTT method. The study found that active isolates were triterpenoid compounds, that is α-amyrin which is active against MCF-7 cells with an IC50 value of 4,57μg/ml and T47D of 10,23μg/ml.

Penulis : SYAMSUDIN , Prof. Dr. M.Biomed., Apt. [PDF File] didownload : 85 x

A RETROSPECTIVE STUDY ON THE POTENTIAL DRUG INTERACTION BETWEEN ANGIOTENSIN CONVERTING ENZYME INHIBITOR OR ANGIOTENSIN RECEPTOR ANTAGONIST AND OTHER DRUGS IN END-STAGE CHRONIC RENAL FAILURE PATIENTS
Abstrak

Background:

Increasing number of chronic renal failure (CRF) patients had reflected an increase in the number of patients with diabetes and hypertension. Therefore, health practitioners would be faced with management of complicated medical problems for the patients of chronic renal disease. In this way, various complications of chronic renal failure would lead to polypharmacy, where the patients receive three to five drugs in a dose. Development of polypharmacy had made the potential of drug interaction greater.

 

Objective:

To determine whether CRF patients admitted to hospital with specific adverse drug reactions were likely to have been prescribed with interacting drugs

 

Design

Retrospective study

 

Setting

The study was conducted at the General Practice Rooms Floor 1 – Floor VI of Central Army Hospital Gatot Soebroto Jakarta. The study was conducted from December 2011 – February 2012. The data were collected in a retrospective way for a year (January – December 2011).

 

Patients

End-stage CRF patients who were having hemodialysis therapy and receiving ACE Inhibitor drugs or Angiotensin II Receptor Antagonist (AIIRA) and receiving treatment at the General Practice Rooms at Central Army Hospital Gatot Soebroto Jakarta

 

Results

During the period of January – December 2011, 84 patients were treated with end-stage CRF at the Central Army Hospital and having routine hemodialysis and 44 patients were receiving therapy with ACE Inhibitor and AIIRA. Other drugs simultaneously given with ACE Inhibitor and AIIRA were captopril-spironolactone, captopril-aspirin, captopril-allopurinol, captopril-KSR, captopril-furosemide, lisinopril-furosemide and valsartan-mefenemic acid. An increase in adverse effects of the drugs was found based on the clinical evaluation and laboratory examination. The adverse effects included hyperkalemia (9,09%), decrease in anti-hypertension effect (6,8%), acute hypotension (40%), and declining renal function (11,36%).

 

Conclusion

The study identifies drug interaction in end-stage CRF patients who received ACE Inhibitor or AIIRA. This study highlights the need for screening prescriptions of for pDDIs and proactive monitoring of patients who have identified risk factors; this helps in detection and prevention of possible adverse drug interactions 

 

 

 

Penulis : SYAMSUDIN , Prof. Dr. M.Biomed., Apt. [PDF File] didownload : 148 x

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