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Peningkatan jumlah pesanan yang diterima tidak sebanding dengan kapasitas produksi yang dimiliki. Salah satu cara untuk meningkatkan kapasitas produksi adalah dengan mengurangi waktu proses produksi. Departemen produksi berusaha untuk mengurangi waktu proses pemotongan untuk meningkatkan efektifitas produksi dengan cara mengganti proses pemotongan material manual dengan menggunakan mesin water jet cutting. Dalam pengadaan mesin ini diperlukan sarana tambahan untuk menunjang pengoperasian mesin tersebut. Karena hal tersebut, perusahaan ingin mengetahui apakah layak dilakukan pembelian mesin water jet cutting dibandingkan dengan tetap menggunakan mesin manual. Penelitian ini ditulis untuk menganalisis kelayakan penggantian mesin pemotongan manual. Analisis penggantian yang dilakukan menggunakan metode net present value (NPV), internal rate of return (IRR) dan benefit cost ratio (BCR) selama periode 8 tahun. Hasil dari NPV didapatkan bahwa besarnya nilai saat ini untuk water jet cutting adalah 3,827,029.48 USD. IRR dari mesin water jet cutting adalh 10.58%, lebih besar dari MARR perusahaan. Nilai BCR dari mesin baru adalah 14.38. Dari hasil tiga analisa tersebut pembelian mesin baru layak dilakukan. Selain itu dengan pembelian mesin water jet cutting, perusahaan dapat melakukan penghematan sebesar 38,345.71 USD pertahun. Efektifitas produksi meningkat sebesar 48.07% dari kondisi saat ini. Maka pembelian water jet cutting layak dilakukan dibandingkan dengan tetap menggunakan mesin pemotongan manual.
Kata kunci : net present value, internal rate of return, benefit cost ratio, penghematan,
efektifitas produksi.

PENGARUH PEMBERIAN SEDIAAN MIKROMINERAL PADA FERTILITAS MENCIT BETINA GALUR DDY

(Effect of Microminerals against Fertility Mice Female DDY Strain)

Ros Sumarny 1 & Pudjiastuti 1

1 Fakultas Farmasi Universitas Pancasila Jakarta

email: rosaries15@yahoo.com

ABSTRACT

Microminerals were needed by the body in very small amounts in which they have important physiological roles in the body including the fertilization of living things. This study aimed to observe the dose and period of administration of the preparation of microminerals in order to improve the fertilization in female mice of DDY strain. The study was conducted on 60 female mice of DDY strain with five different concentration of microminerals namely 1.5 ; 3.0 ; 6.0 ; 12 and 24 % (v/v). The study was continued using three different period of administration namely 10 days before the mating, 18 days after the mating and 28 days (10 days followed by 18 days after mating) in which the method used was designed in the manner of bigamy ie 1 male mouse caged with 2 female mice. The preparation was given every day during three different period of the observation. The indicator of fertilization was macroscopically observed by counting the number of fetus in the uterus of female mice on 19th day after the appearance of a vaginal plug. As conclusion, the greatest number of fetus was obtained from the administration of the preparation with concentration of 6 % that was given for 10 days before the mating.

Keywords: microminerals, fertilization, female mice

AKTIVITAS ANTIPROLIFERASI EKSTRAK RIMPANG TEMUPUTIH

[Curcuma zedoaria (Christm) Roscoe] TERHADAP SEL LESTARI TUMOR SECARA

IN VITRO

{Anti-proliferation Activity of Curcumae Extracts [Curcuma zedoaria (Christm) Roscoe] 

against Tumor Cell Lines In-Vitro}

Ros Sumarny¹, Bambang P. Priosoeryanto², Meliana Tham¹, Hannes¹

¹Fakultas Farmasi Universitas Pancasila Jakarta

² Fakultas Kedokteran Hewan Institut Ppertanian Bogor

email: rosaries15@yahoo.com

ABSTRACT

Screening of candidate of antitumor compounds begins with research on lethality test on microorganisms such as shrimp larvae. The study is further continued to test the cytotoxicity of various polarities of plant extracts against various type of tumor cell lines. This study aimed to obtained the value of Lethality Concentration Fifty (LC50) of the water, methanol, ethyl acetate and n - hexane extract of curcumae on shrimp larvae mortality using Brine Shrimp Lethality Test ( BSLT) followed by observing the cytotoxicity against MDCK cell lines (Madin-Darby Canine Kidney Epithelial Cells) and MCA - B1 cell lines (canine oral acanthomatous epulis). The results showed that n-hexane extract demonstrated the highest toxicity with LC50 value of 66 ppm whereas IC50 value of 81.6 ppm for MDCK cells and IC50 value of 77.4 ppm for MCA - B1 cells.

Keywords: Curcumae extracts, anti-proliferation, MDCK cells, MCA-B1 cells

Alga Merah (Gracilaria verrucosa) sebagai Bahan Bakto Agar

 Shirly Kumala, Ros Sumarny, Rum Rachmani, dan Atut Ruswita

 Abstract : The used of bacto agar in microbiological studies increased tremendously, however, up till now, to fullfill its high demand the scientist were still relying on imported bacto agar eventhough domestic production of bacto agar was as good and reliable as those produced commercially overseas. The current study  we focuse on  the production of bacto agar from red algae Gracilaria verrucosa using fell press technique; followed by quality  analysis of the product. Red algae samples were collected from two different locatyions (Bekasi and Subang). Quality of the product was tested  for its content, acid insoluble, ash content, overall ash content, pH, gel strength and its ability to be use as culture  media to culture Escherichia coli and Staphylococcus aureus. Microbiological test was performed via pour plate. The results clearly demonstrated thar red algae sample from Bekasi produced bacto agar that meets the criteria of commercial bacto agar. It has 10,3% water content, 3,9% overall ash content, 0,4% acid insoluble ash content, pH of 7,3 and gel strength of 600,8-600,2 g/square cm.

Keyword. Bacto agar, red Algae, Gracilaria verrucosa , Microbe media