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2013-05-08 08:51:40
Untag Telah Luluskan 35.000 Sarjana
2013-05-08 08:51:25
FKIP Untirta Gelar Gebyar Hardiknas 2013
2013-05-08 08:50:53
Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

PENGARUH PENGGUNAAN ISOFLURAN TERHADAP PERUBAHAN KADAR MALONDIALDEHYDE DAN RASIO EKSTRAKSI OKSIGEN PADA PASIEN PASKA KRANIOTOMI
Abstrak

Traumatic brain injury can increase the production of free radical which is shown by the increasing of MDA content and cell death shown by the ability of oxygen usage by the cell, in this case by observing the oxygen extraction ratio. Isoflurane as neuroprotector can prevent the effect of  free radical. This research aim to get some anesthesi inhalation agent that good enough for neuro anesthesi in brain protection, in term of the decreasing MDA or free radical content and  the oxygen extraction ratio during pre operative, durante operative and post operative. The subject of this research are 19 patients which had craniotomy operation at DR. Sardjito hospital, elective or emergency. Craniotomy operation had done by used of anesthesi with isoflurane inhalation. Blood sample took from jugularis interna vein MDA testing and vein blood gas analyze (SvO2). Blood gas analyze artery (SaO2) took from radialis artery blood sample. Examination had done during pre operative, durante operative and post operative.

The result showed MDA had decreased as 7,49% at durante operatif than at pre operatif and MDA blood content had decreased as 17,30% at post operative than at durante operatif. Oxygen extraction ratio had increased as 20,43% at durante operatif than at pre operatif and had increased as 23,74% at post operative than at durante operatif. It could be conclude that isoflurane had decreased free radical which shown by decreasing MDA at durante operative and post operative than pre operative and isoflurane had increased oxygen extraction ratio which shown by increasing of oxygen usage by the cell at durante operative and post operative than pre operative on patient trauma brain injury.

Penulis : NI MADE DWI SANDHIUTAMI, S.SI,M.KES.,APT [PDF File] didownload : 68 x

UJI AKTIVITAS ANTIOKSIDAN MINYAK BUAH MERAH (PANDANUS CONOIDEUS LAM.)SECARA IN VITRO DENGAN METODE DPPH (2,2-DIFENYL-1-PIKRIL HIDRAZIL DAN LINOLEAT-TIOSIANAT
Abstrak
Penulis : NI MADE DWI SANDHIUTAMI, S.SI,M.KES.,APT [PDF File] didownload : 41 x

Antioxidant activity of white and red cabbage (Brassica oleracea L.var capitata L.) using DPPH
Abstrak

Cabbage (Brassica oleracea L.var capitata L) is one of many vegetables in Indonesia. There are two kinds of cabbage white and red cabbage. Phytochemical screening and antioxidant activity have been carried out of raw, steamed and boiled using DPPH. The result of phytochemical screening of white and red cabbage contains flavonoids and steroid/triterpenoid. The result of DPPH method showed that the IC50 value of raw red cabbage, steamed and boiled respectively were 35.84 ppm, 56.83 ppm, and 80.07 ppm. The IC50 value of raw, steamed and boiled white cabbage respectively were 161.23 ppm, 217.51 and 304.59 ppm. From the results showed that antioxidant activity raw red cabbage is the highest but lower than vitamin C as positive control (IC50 = 7,39 ppm)

Penulis : YUNAHARA FARIDA , Dr [PDF File] didownload : 75 x

Biological activity test of extracts and fractions there of keladi tikus leaves (Typhonium flagelliforme (Lodd.) Blume
Abstrak

Abstract: Typhonium flagelliforme (keladi tikus), from familia Araceae, is widely used as an alternative therapy to treat various cancer. In this study, the leaves of keladi tikus plant were extracted using methanol and then partitioned using n-hexane, ethylacetate, and n-buthanol sequentially. The phytochemical screening, and the biological activity using brine shrimp lethality (BSLT) were carried out in this research. The result of phytochemical screening showed that the leaves contained steroids, flavonoids, and saponins. The results of BSLT method showed that the most active extract was ethylacetate extract (LC50 = 55 µg/mL) and the lowest one was the n-buthanol extract (LC50 = 384 µg/mL). The ethyl acetate extract was tested for cytotoxic activity on T-47D cells using the MTT assay method. The IC50 value was 30 µg/mL. The ethylacetae extract was then fractioned by VLC using gradient elution (DCM, isopropanol, and methanol); the fractions were tested using BSLT. The results from the nine fractions showed that  the 5th fraction was the most active causing 97% mortality. It can be concluded that the ethyacetate extract is potential theraupetic bioactive compound.

 

Keywords :   Keladi tikus (Typhonium flagelliforme (Lodd). Blume), Brine Shrimp Lethality Test (BSLT), MTT assay.

Penulis : YUNAHARA FARIDA , Dr [PDF File] didownload : 67 x

Isolation and identification of a chemical compounds in n-hexane phase from the methanol extract of keladi tikus leaf (Typhonium flagelliforme Lodd. Blume, Araceae
Abstrak

Abstract: Keladi tikus (Typhonium flagelliforme (Lodd.) Blume ) is a plant which empirically has efficacy in treating cancer. In this study, n-hexane phase was fractionated using Vacuum Liquid Chromatography (dichloromethane; isopropanol 98:2 (1:1) and Column Chromatography (SiO2, n-hexane-ethylacetate =3:1) and then each fraction was tested for toxicity with BSLT (brine shrimp lethality test.) method. The most active fraction was purified by TLC preparative and the pure compound was identified by using UV-Vis Spectrophotometer, IR Spectrophotometer, and Gas Chromatography-Mass Spectrometer. The result showed that fraction H.2.5 was the most active fraction with percent mortality 90% and one of the compounds contained in the n-hexane phase of keladi tikus leaves is phytol compound that had 91% similarity with the molecular formula C20H40O and the molecular weight of 296.31 

Keywords : isolation,  keladi tikus, Typhonium flagelliforme (Lodd). Blume, BSLT

Penulis : YUNAHARA FARIDA , Dr [PDF File] didownload : 53 x

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