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Publikasi Penelitian Dosen

Identifkasi Senyawa Flavonoid dalam Fraksi n-Butanol Taraxacum offcinale, Asteraceae
Abstrak
Penulis : RATNA DJAMIL , Dr MSi Apt [PDF File] didownload : 48 x

IDENTIFICATION OF SECONDARY METABOLITES AND ANTIOXIDANT ACTIVITY OF EXTRACT BINAHONG LEAVES Anredera cordifolia (Ten.) Steenis
Abstrak

IDENTIFICATION OF SECONDARY METABOLITES AND  ANTIOXIDANT ACTIVITY OF EXTRACT BINAHONG LEAVES Anredera cordifolia (Ten.) Steenis

 

Ratna Djamil1, Wahyudi PS2, Wahono S3

1Faculty of Pharmacy Pancasila University,Jakarta 12640,Indonesia

2Department of Chemistry,Faculty of Mathematics and Science, University of Indonesia,Depok 1624 Indonesia

3Agency for the Assessment and Application of Technology,Indonesia

ratnadj_ffup@yahoo.co.id

 

 

Binahongs leaves (Anredera cordifolia Ten.) Steenis) traditionally used to treat many degenerative diseases such as, anti-diabetic, prevents strokes, anti-hepatotoxic, analgesic, anti- inflammatory and treatment of fractures. One cause of degenerative diseases is free radical in which the negative effects of free radicals can be inhibited by an antioxidant. The research studied the antioxidant activity of extracts binahongs leaf (Anredera cordifolia Ten) Steenis). Binahong leaf  extracted with  methanol solvent and  then  partitioned witseveral solvent n- hexane, ethyl acetate, and n-buthanol. Extracts were tested with the reagent 2,2-Diphenyl-1- picrilhydrazil (DPPH). From  the results of  the partition showed the most active extracts as antioxidants was ethyl acetate extract with IC50 values 66.80 ppm. The most active extracts was fractionated using vacuum column chromatographic resulted 9 fractions  in which the fraction 7,

3, 4 and 6 showed the highest activity with IC50 values of 47,80 ; 67,99 ; 77,71 and 88,86 µg/mL. For comparison purposes with the ascorbic acid IC50  value 4,19 µg/mL. The result of phytochemical  screening  exhibited  that  th ethyl   acetate  extracts  contained  secondary metabolites such as flavonoids, saponins, steroids / triterpenoids and coumarins.

 

 

 

Key words:Anredera cordifolia, Antioxidant activity

Penulis : RATNA DJAMIL , Dr MSi Apt [PDF File] didownload : 36 x

ISOLASI DAN IDENTIFIKASI JENIS SENYAWA FLAVONOID DALAM FASE n-BUTANOL DARI EKSTRAK METANOL DAUN DARUJU (Acanthus ilicifolius Linn.), Acanthaceae.
Abstrak

ISOLASI DAN IDENTIFIKASI JENIS SENYAWA FLAVONOID DALAM FASE

n-BUTANOL DARI EKSTRAK METANOL DAUN DARUJU (Acanthus ilicifolius Linn.), Acanthaceae.

  Ratna Djamil, Lissa Desfonda

Fakultas Farmasi Universitas Pancasila

 

Abstract

Ilicifolius Acanthus Linn. is one derived from medicinal plants familia Acanthaceae are known to contain

flavonoids, but not yet known about the classes and types of flavonoid compounds contained in these plants. Based on this, then do research about ilicifolius Acanthus Linn., With the aim to know the classes and types of flavonoid compounds contained in these plants. Our research methods include the collection and provision of materials, phytochemical screening, the preliminary investigation of flavonoid, flavonoid isolation and identification of isolates using the method of ultraviolet-visible light. Results of phytochemical screening of crude drugs and known in the powder in n-butanol phase of methanol extracts of leaves contained daruju flavonoids, saponins, tannins, steroids and coumarins. The results of identification of flavonoid compounds suspected of classes and types are as follows flavonoidnya NB-III isolates suspected of flavonol compounds with hydroxyl group on the 3,5,7,8 positions and clusters prenil oxygenation in position 6. IV isolates suspected of flavonol compounds with hydroxyl group at positions 3, 5, 7, prenil group at position 6 and O -ring diOH B. NB-VI isolates suspected of flavanone compounds with hydroxyl group at position O-diOH in ring A and 6.7 o7.8 in OH.

 

Keywords    :  Ilicifolius Acanthus Linn., Acanthaceae, flavonoid phytochemical screening, n-butanol phase, ultraviolet-visible light, sliding reagent.

Penulis : RATNA DJAMIL , Dr MSi Apt [PDF File] didownload : 41 x

Phytochemical and Biological Screening of Anredera cordifolia (Ten)Steenis Leaves using Artemia salina (Brine Shrimp Test)
Abstrak

Phytochemical and Biological Screening of Anredera cordifolia 

(Ten)Steenis Leaves using Artemia salina (Brine Shrimp Test) 

 

 

Ratna.D1,2, Wahyudi.P2, Wahono.S3, Heri.A2

1Faculty of Pharmacy Pancasila University,Jakarta 12640,Indonesia

2Department of Chemistry,Faculty of Mathematics and Science, University of Indonesia,Depok 1624 Indonesia

3Agency for the Assessment and Application of Technology,Indonesia

Email:ratnadj_ffup@yahoo.co.id

 

 

Abstract

 

 

 

 

 

The leaves of Anredera cordifolia (Ten)Steenis is Indonesian herb that famous for  medicinal activity. Qualitatif phytochemical screening using standard laboratory procedure was carried out for flavonoid, saponine, steroid/triterpenoid and coumarine. Brine shrimp letha lity bioassay of methanol, n- hexane, ethyl acetate and n-butanol extracts of the leaves showed these extracts were moderately cytotoxic. The LC50  using Probit analysis method for methanol, n-hexane, ethyl acetate and n-butanol extracts were 50,77; 1481,84; 29,63; and 60,8 g/ml respectively. Based on the result, ethyl acetate extracts was fractionated by VLC using gradient elution with dichloromethane-isopropanol and methanol. Its combination  gave 10 fractions and it was screened by Brine shrimp Test. Six  of the ten fractions showed significant toxicity to the brine shrimp ( < 5 g/ml) which are the 1st, 2nd, 3rd, 7th, 9th and

10th fraction.

This Study concluded that ethyl acetate extracts maybe contain bioactive compound of potential therapeutic.

 

 

 

Key words:Anredera cordifolia,Phytochemical,Biological screening

Penulis : RATNA DJAMIL , Dr MSi Apt [PDF File] didownload : 42 x

IDENTIFIKASI SENYAWA FLAVONOID DALAM FASE n-BUTANOL DARI EKSTRAK METANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis)
Abstrak

IDENTIFIKASI SENYAWA FLAVONOID DALAM FASE 

n-BUTANOL DARI EKSTRAK METANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis)

 

 

Ratna Djamil, Wiwi Winarti, Ernie

Fakultas Farmasi Universitas Pancasila email@ratnadj_yahoo.com

ABSTRAK

Berdasarkan  literatur dan penelitian yang telah dilakukan diketahui beberaspesie tanaman familia Basellaceae yaitu Anredera scandens (L.) MoqBasella rubra Linn. atau Basella alba Linn atau Basella cordifolia Lamk, Anredera cordifolia  (Ten.) Steenis diketahui mengandung senyawflavonoid. Namun belum ada data mengenai golongan dan jenis senyawa flavonoid yang terkandung dalam spesies tanaman tersebut. Hal ini mungkidisebabkan masih terbatasnya penelitian mengenai tanaman tersebut. Berdasarkan hal tersebut, maka dilakukan penelitian terhadap salah satu spesiedari Basellaceae yaitu Anredera cordifolia  (Ten.) Steenis. Penelitian yang dilakukan bertujuan untuk mengetahui golongan dan jenis senyawflavonoid yang terkandung dalam salah satu spesies Basellaceae yaitu tanaman anredera cordifolia (Ten.) Steenis. Tahapan penelitian yang dilakukameliputi pengumpulan dan penyediaan bahan, penapisan fitokimia, pemeriksaan pendahuluan senyawa flavonoid, isolasi golongan s enyawa flavonoid dan identifikasi isolat menggunakan metode spektrofotometri ultraviolet-cahaya tampak. Hasil penapisan fitokimia diketahui dalam fase n-butanodari ekstrak metanol daun binahong terkandung senyawa flavonoid, saponin, triterpenoid, kumarin dan kuinon. Hasil penelitian identifikasi senyawflavonoid  diduga golongan dan jenis senyawa flavonoidnya adalah sebagai berikut isolat NB VII diduga adalah senyawa flavonol dengan gugus Opada posisi 3, 5, 7, 4 dan terdapat O-diOH  pada cincin A (6,7) atau (7,8) serta terdapat oksigenasi pada 6 atau 8. Isolat NB-VIII diduga adalasenyawa flavon dengan gugus OH  pada 5, 7, 4 dengan gugus prenil pada posisi 6 serta terdapat gugus O-diOH pada cincin A (6,7) atau (7,8sedangkan Isolat NB-IX diduga adalah senyawa flavonol (3-Op [PDF File] didownload : 49 x


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