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2013-05-08 08:51:40
Untag Telah Luluskan 35.000 Sarjana
2013-05-08 08:51:25
FKIP Untirta Gelar Gebyar Hardiknas 2013
2013-05-08 08:50:53
Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

Acute and subchronic toxicity of potential ethylacetate fraction of propolis

Propolis from Indonesia is widely used in traditional medicine and is reported to have a broad spectrum of pharmacological activities. However nothing is known
about its toxicity. The objective of this study was to evaluate the acute and subchronic toxicity of the potential ethylacetate extract of Indonesian propolis in mice.
The acute toxicity LD50 was estimated to be 14,8597g/kgBW. In the subchronic toxicity, there was no mortality recorded among the animals when varyng doses
of the fraction (500 and 1000mg/kg-1body weight) were administered orally for 36 days consecutively. The weekly body weight of the mice showed no significant
differences between the control and the mice treated with the fraction except on the last week (day 36). There was neither any gros lession nor histopathological
changes observed in organs examined. These finding suggest that the fraction of propolis could be relatively safe when administered orally in mice.

Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 41 x

Uji Toksisitas Subkronik Ekstrak Eatanol Kulit Batang Jaloh (Salix tetrasperma Roxb) Terhadap Parameter Fungsi dan Gambaran Histopatologi Organ Ginjal Tikus

Uji Toksisitas Subkronik Ekstrak Eatanol Kulit Batang Jaloh (Salix tetrasperma Roxb) Terhadap Parameter Fungsi dan Gambaran Histopatologi Organ Ginjal Tikus

Ros Sumarny, Sugito, Eko, Andri

[PDF File] didownload : 65 x

Subchronic Toxicity Effect of Formalin Residue in Fish on The Mouse Liver

Subchronic Toxicity Effect of Formalin Residue in Fish on The Mouse Liver

Jovita Tri Murtini, Yeni Pratiwi Puspitasari, Ros Sumarny



Research on subchronic toxicity effect of formalin residue in fish on the mouse liver has been done. This research was aimed to give scientific explanation concerning illegal application of formalin in food products, including fish. Formalin is harmful and thereby is banned to be used as perservative agent. However, in some places formalin is apllied to extend the shelf life of either fresh or processed  fish products. In term of the research treatments, the mice were divided into four groups : negative control, 1st dosage  (formalin residue 3 ppm), 2nd dosage (formalin residue 6 ppm), 3rd dosage  (formalin residue 12 ppm), each group was tested on 18 mice. Blood and histopatology analysis were conducted every 2 weeks for 6 weeks. The research resulted that GOT concentration highly increased in the 2nd week and GPT concentration highly increased in the 4th week, while there was no decreasing GPT and GOT concentration during 2 weeks recovery. Increasing formalin concentration in fish meal caused the increase of GOT and GPT level. The histopatology analysis showed that mouse liver cell degerenated in the  2nd week at the residue of 3 ppm and necroted at formalin residue of 6 ppm and 12 ppm. After 2 weeks recovery, there was no indication of mouse liver recovery.


Keywords: subchronic toxicity, formalin residue, fish mouse liver.  

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 61 x

Penghambatan Ekspresi Gen dengan Antisense Oligonukleotida sebagai Upaya

Due to the development of biomolecular science eg.overexpression genes, genes that cause diseases can be identified. Based on this fact, researchers developed a therapeutic strategy by inhibiting the gene expression using oligonucleotide antisense. Therapy using oligonucleotide antisense was based on a natural process of gene expression. Spesific artificial antisense will match complementary with DNA and mRNA. By this process the transcription will stop. The effort of therapy is relatively new but a few have been cartried out in clinical trial phase. Obstacles are encountered in reaching the target cell by oligonucleotide antisense.

Keyword : oligonucleotide, antisense, gene expression, therapy



Penulis : DIAN RATIH L , Dr., M.Biomed., [PDF File] didownload : 84 x

Secretion of Indoleamine 2,3-Dioxygenase, An Immunomodulatory Substance, By adipose-Derived Mesenchymal Stem Cell

Lipoaspirate, a wasted by product from liposuction procedure recently has been shown to contain abundant adipose-derived-mesenchymal stem cells (MSCs). Mesenchymal stem cells have been studied in many research areas to regenerate many cell lineages. In addition, MSCs have immunomodulatory effect. This capability has been utilized in several clinical studies in hematopoetic stem cell and organ transplantation as a strategy to reduce the risk of Graft versus Host Disease (GvHD). It has been reported that the ‘stimulated’ MSC is able to secrete substances to suppress tissue rejection. One of the substances was known to be indoleamine 2,3-dioxygenase (IDO).  A previous study has characterized the secretion of IDO by bone marrow-derived MSCs stimulated by an inflammatory mediator interferon gamma (IFNγ). Indoleamine 2,3-dioxygenase has been detected using Western blot analysis and by High Performance Liquid Chromatography (HPLC) assay. The aim of this study was to detect the presence of IDO in adipose-derived MSCs culture with and without INFγ stimulation. Our study showed that adipose-derived-MSC stimulated with IFN γ significantly secreted high level of IDO as detected by Enzyme-Linked Immuno Sorbent Assay (ELISA). Despite its property as a proinflammatory mediator, IFN γ has shown to be able to induce IDO secretion in MSC culture which suggests the immuno modulatory effect of MSC. This study clearly demonstrates the potential application of adipose-derived MSC in the immunomodulatory strategy for allogenic transplantation. 


Keyword : mesenchymal stem cell, indoleamine 2,3-dioxygenase, IFNγ


Penulis : DIAN RATIH L , Dr., M.Biomed., [PDF File] didownload : 63 x

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