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Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

Pengaruh pemberian ekstrak kering rimpang temu putih (Curcuma zedoria. Rosc.) per oral terhadap beberapa parameter gangguan ginjal pada tikus putih jantan
Abstrak

Rimpang temu putih (Curcuma zedoria. Rosc.) secara empiris digunakan untuk mengobati kanker dan biasanya digunakan dalam jangka waktu yang lama. Dari hal tersebut maka penelitian ini bertujuan untuk mengetahui keamanan pemberian sediaan tersebut dengan melihat pengaruhnya terhadap gambaran fungsi ginjal tikus putih jantan selama 12 minggu pemberian. Sebanyak 80 ekor tikus putih jantan umur 8 minggu (180-200g) dibagi menjadi 4 kelompok, masing-masing kelompok 20 ekor. Kelompok 1 sebagai kelompok kontrol, kelompok 2,3 dan 4 masing-masing diberi ekstrak kering rimpang temu putih dosis 9 mg/200g BB, 18 mg/200gBB dan 27 mg/200 g BB. Ekstrak kering temu putih diberikan setiap hari selama 12 minggu dan sample darah dan urine serta ginjal diambil dengan membunuh 5 ekor tikus per kelompok pada minggu ke 4, 8, 12 dan 16 setelah pemberian sediaan. Contoh serum dianalisis kandungan kreatinin dan contoh urine dianalisis kadar kreatinin, pH dan berat jenis serta bentuk dan gambaran histologik ginjal juga diamati. Ekstrak kering temu putih tidak menyebabkan perbedaan yang nyata diantara kelompok kontrol dan perlakuan terhadap kadar dalam serum dan kreatinin, pH, Bj pada urine (P>0,05) baik menurut dosis perlakuan dan lama pemberian. Sehingga dapat disimpulkan bahwa pemberian jangka lama ekstrak temu putih sampai dosis 27mg/200g bb aman terhadap hewan coba tikus putih dan aman untuk digunakan pengobatan jangka panjang.

Kata kunci: Curcuma zedoria. Rosc, kimia urine, ginjal.

http://mfi.farmasi.ugm.ac.id/?pilih=news&aksi=lihat&id=133

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 92 x

Antidiabetic Activity of Active Fractions of Leucaena Leucocephala (lmk) Dewit Seeds in Experiment Model
Abstrak

A study was conducted on antidiabetic test of active fractions of methanol extract
from Leucaena leucocephala (lmk)DeWit seeds using alloxan-induced rats. Fractionation
was conducted on active fractions using column chromatograph. The most active fractions
in the previous study were analyzed with thin layer chromatography (TLC) using mobile
phase of chloroform-methanol (5:1), chloroform–methanol (2: 1), chloroform-methanolwater
(5: 5: 1) on the isolates yielded with oral glucose tolerance test and identification.
The result findings show that methanol extracts have a greater antidiabetic activity; and 5
isolates resulted from the isolation of methanol extracts. The result of bioactive compound
identification was glycoside compounds with monosaccharide galactose clusters and many
other saccharides. It was concluded that active fractions of Leucaena leucocephala
(lmk)DeWit seeds had antidiabetic activities and their bioactive compounds constitute
glycoside compounds with monosaccharide galactose clusters and many other saccharides.

Keywords: L. leucocephala (lmk)D eWit seeds, antidiabetes, alloxan, oral glucose tolerance

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 84 x

The Anti-Proliferation Assay of Bioactive Fraction from curcuma zedoaria Rhizome
Abstrak

Abstract

 

This study was aimed to investigate the anti-proliferation activity of the bioactive fraction from Curcuma zedoaria. The dried powder of Curcuma zedoaria rhizome was extracted using continuous maceration method with n-hexane, ethyl acetate and methanol 50%, respectively. Brine Shrimp Lethality Test (BSLT) has been used as a preliminary test for screening the antiproliferation activity of three extracts. Ethyl acetate extract showed the highest  activity  of all and it became the subject for fractionation using column chromatography with silica gel GF as stationary phase and the combination of n-hexane:ethyl acetate in various gradient concentration as mobile phase. The fractionation process produced five fractions, namely fraction A, B, C, D and E. The anti-proliferation assay of the resulted fractions was determined with tumor cell lines of HeLa, K562 and WEHI 164. The study found that fraction C (15 ppm) could inhibit the proliferation of HeLa cells by 32%, K562 cells by 55% and WEHI cells by 49%.

 

Key words: Curcuma zedoaria,  bioactive fraction,  anti-proliferation


Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 84 x

Simultaneous Determination of Caffeine and Nicotinamide in Energy Drinks by First-Order Derivative Spectrophotometry
Abstrak

A simple analytical method is described for the simultaneous determination of caffeine  and nicotinamide in powder form of energy drinks. The first-order derivative UV-spectrophotometry was employed using water as solvent, the zero-crossing wavelengths were found at 273 and 261 nm for caffeine and nicotinamide, respectively. The calibration graphs were rectilinear up to 25.4 mg/mL and the relative standard deviations values were lower to 1.7 %  for both analytes. The limits of detection were 0.669 mg/mL caffeine and 0.550 mg/mL nicotinamide, respectively with recovery values of 93.44 to 104.65% for caffeine and 88.89 to 104.26% for nicotinamide.

Penulis : LILIEK NURHIDAYATI , M.Si [PDF File] didownload : 108 x

KONTRIBUSI STRUKTUR PENGENDALIAN INTERN DALAM PENENTUAN LINGKUP AUDIT (STUDI PADA BAWASDA KOTA DEPOK)
Abstrak

This research was conducted with the aim to identify and prove the effect of simultaneous and partial characteristics of the preparation of the budget that includes: contribution to the control environment, risk assessment, control activities, information and communication, monitoring in determining the scope of audit. Design used in this study is a survey method, survey methods included descriptive research. This study aims to describe and test the hypothesis of a causal relationship between independent variables and dependent variables, either simultaneously or partially. The results showed that: (a) Elements of the internal control structure that consists of the control environment, risk assessment, control activities, information and communication, monitoring of this joint has a contribution in determining the scope of the audit; (b) The elements of internal control consists of the control environment, risk assessment, as well as information and communication, individually marked regression coefficient is negative or has a negative relationship. The relationship between the internal control structure with the scope of the audit means that if the internal control structure that consists of the control environment, risk assessment, as well as information and communication in effective business units will not produce a broad scope of the audit.

Keywords: internal control structure, scope of audit.

Penulis : TRI WIDYASTUTI, Prof.Dr. SE,MM,Ak,CA [PDF File] didownload : 47 x

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