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2013-05-08 08:51:40
Untag Telah Luluskan 35.000 Sarjana
2013-05-08 08:51:25
FKIP Untirta Gelar Gebyar Hardiknas 2013
2013-05-08 08:50:53
Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

Quantitative Structure-Activity Relationship Analysis of Antimalarial Compound of Mangostin Derivatives Using Regression Linear Approach
Abstrak

Quantitative electronic structure-activity relationship (QSAR) analysis of a series of mangostin derivatives as antiplasmodial compounds
have been conducted using atomic net charges (q), dipole moment (μ) ELUMO, EHOMO, polarizability (a), log P and massa molecular as the
descriptors. The descriptors were obtained from computational chemistry method using semi-empirical PM3. Antiplasmodial activities
were taken as the activity of the drugs against chloroquine-resistant plasmodiumfalciparum FCR3 strain and are presented as the value of
ln (1/IC50) where IC50 is an effective concentration inhibiting 50 % of the parasite growth. The best model of QSAR model was determined
by multiple linear regression method and giving equation of QSAR: ln 1/IC50 = -189.029-(752.054) qC5 + (1249.672)qO6 + (3134.359)
qC9 + (1174.323) qC10 + (329.121)qC13 - (1.409)μ + (75.214) ELUMO - (23.683) ELUMO - (2.156) a- (3.372) log P + (0.309) MM. The
equation was significant on the 95 % level with statistical parameters: n = 15; r = 0.951; r2 = 0.905; SE = 1.326498; Fcalc/Ftable = 1.029 and
gave the PRESS = 5.650972. Its means that there were only a relatively few deviations between the experimental and theoretical data of
antimalarial activity.

Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 37 x

Heme Polymerization Inhibitory Activities of Xanthone from G. parvifolia (Miq) Miq Stem Bark as an Antimilarial
Abstrak

A study had been conducted to isolate, to identify and to test heme polymerization inhibitory activities of G. parvifolia (Miq)Miq stem
bark active compounds with antimalarial properties. UV, IR, RMI 1D (1H NMR and 13C NMR) and RMI 2D (COSY, HMQC and HMBC)
and mass spectra were used for identification. Heme polymerization inhibitory activity assay was conducted in vitro by measuring b-
hematin formation using ELISA reader. The study revealed that active isolates derived from xanthone compounds, 1,3,6-trihydroxy-2-(3-
methylbut-2-enyl)-7-methoxy-8-(3-methylbut-2- enyl)xanthen-9-on. HPIA assay showed that the compounds acted by inhibiting weak
heme polymerization activities.

Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 54 x

Biological activity of Propolis from Jawa
Abstrak
Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 47 x

The effect of Garcinia parvifolia (Miq)Miq extract against liver damage of Plasmodium berghei infected mice
Abstrak

Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 35 x

CYTOTOXIC ACTIVITY OF TRITERPENOID FRACTION OF INDONESIAN PROPOLIS ON HUMAN BREAST CARCINOMA CELL LINES
Abstrak

A study to identify chemical compound of Indonesian propolis and to examine its cytotoxic activity of human breast cancer cells (MCF-7 and T47D) had been conducted. Identification was conducted by using spectrometries of UV, IR, NMR (1H-NMR and 13C-NMR) and mass spectra; while cytotoxic test was conducted with MTT method. The study found that active isolates were triterpenoid compounds, that is α-amyrin which is active against MCF-7 cells with an IC50 value of 4,57μg/ml and T47D of 10,23μg/ml.

Penulis : SYAMSUDDIN , Prof. Dr. M.Biomed. [PDF File] didownload : 51 x

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