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2013-05-08 08:51:40
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2013-05-08 08:51:25
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2013-05-08 08:50:53
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Publikasi Penelitian Dosen

Physical Characteristics of Capsule of keladi tikus extract (Typhonium divaricatum L.Decne) from spray drying method using maltodextrine
Abstrak

Keladi tikus (Typhonium divaricatum (L.) Decne), one of many wild plants, are consumed by cancer patients. Keladi tikus have antioxidant activity which can resist the effects of free radicals. This research including phytochemical screening using the Farnsworth method, a test of antioxidant activity using DPPH free radical reduction (1.1-diphenyl-2-pikrilhidrazil), drying of keladi tikus extracts (n-hexane and methanol) by spray drying method and formulation granule extract into a capsule dosage form have been evaluated. Concentration of maltodextrin as filler used for the spray drying process were 35%, 40% and 45% for n-hexane extract and 40%, 45% and 55% for methanol extract. Capsules evaluated weight uniformity, disintegration time and dissolution rate. The results showed that the phytochemical screening of methanol extracts indicate flavonoids, saponins and steroids / triterpenoid, in n-hexane extract showed the presence of steroid / triterpenoid. Antioxidant activity by DPPH test showed IC50 values of the extract methanol was 56,63 ppm. Results of uniform weight of capsule were as follows formula I-III: 0,3718 ± 0,0034 g-0, 3673 ± 0,0039 g and formula IV-VI 0,3783 ± 0,0053 g -0, 3812 ± 0, 0047 g. Disintegration time of capsule was formula I-III: 6.57 - 8.13 minutes and formula IV-VI: 7.80 - 9.19 minutes. Dissolution rate of capsule showed that the concentration of maltodextrin increased as the increasing of dissolution rate capsule. Based on one-way analysis ANVA of disintegration time and dissolution rate with variation concentration of maltodextrin concluded that there was a statistically significant difference.

 

Keywords: Capsule dosage form, Physical characteristic, Keladi tikus extract,  Maltodextrine, Spray drying

Penulis : YUNAHARA FARIDA , Dr [PDF File] didownload : 35 x

Perbandingan spektrum KLT-densitometri dari ekstrak etanol jahe (Zingiber officinale Rosc.) dengan pelarut etanol yang berbeda konsentrasinya,
Abstrak

Jahe (Zingiber officinale Rosc.) telah lama dimanfaatkan secara empiris oleh masyarakat Indonesia sebagai obat tradisional. Pada saat ini industri obat tradisional mulai mengembangkan tanaman yang berkhasiat obat tidak saja dalam bentuk serbuk simplisia tetapi sudah dibuat dalam bentuk ekstrak. Pada pembuatan ekstrak, industri obat tradisional menggunakan pelarut yang tidak berbahaya seperti etanol. Penelitian ini bertujuan membandingkan spektrum serapan secara KLT densitometri rimpang jahe yang diekstraksi menggunakan etanol dengan konsentrasi 50, 70 dan 96%. Masing-masing ekstrak kemudian dikromatografi dengan eluasi dua kali berturut-turut menggunakan cairan eluasi pertama : toluen-etil asetat-asam format (90:8:2) dan eluasi kedua : toluen-etil asetat = 90:10. Kromatogram yang diperoleh diperiksa spektrumnya secara KLT densitometri pada panjang gelombang 217, 254, 284 dan 366 nm. Spektrum yang diperoleh dibandingkan untuk melihat persamaan dan perbedaannya. Hasil penelitian menunjukkan ekstraksi dengan etanol 50% menghasilkan rendemen yang lebih besar dibandingkan  etanol 70 dan 96%. Dari hasil KLT densitometri menunjukkan ekstrak etanol 96% memberikan bercak yang lebih banyak dibandingkan ekstrak etanol 50 dan 70%.

Penulis : YUNAHARA FARIDA , Dr [PDF File] didownload : 80 x

Cytotoxic Activity of Ocimum americanum L. Leaves Against T47D Breast Cancer Cells using MTT Assay
Abstrak

Abstract: This is an advance experiment of the previous cytotoxic screening test using BSLB method which resulted that methanol extract of Ocimum americanum L. leaves has the highest cytotoxicity potential. In this experiment, extraction of Ocimum americanum L. leaves have been conducted by maceration using  n-hexane, ethyl acetate, and methanol solvent. These extracts are then tested for their cytotoxic activity. The purpose of this experiment is to detect the cytotoxic activitiy of various extract of Ocimum americanum L. leaves against T47D breast cancer cells in vitro. The MTT assay method was used with fraction concentration test series of 10, 20, 40, and 80 µg/mL. LC50 value was used as a parameter for cytotoxicity and obtained by probit analysis. National Cancer Institute recommended that any extracts generates LC50 below than 30 µg/mL is considered to possess cytotoxic activity. The results indicate that LC50 of n-hexane extract of Ocimum americanum L. leaves could not be determined in sampel concentrations of ≤ 80 µg/mL. Whilst the LC50 value can be determined in the other two extracts. The LC50 value of ethyl acetate and methanol extract of Ocimum americanum L. leaves were 26.7 µg/mL and 276 µg/mL, respectively. It can be concluded that ethyl acetate extract of Ocimum americanum L. has potential  cytotoxic activity against T47D breast cancer cells. 

 

Keywords: cytotoxic, extract, MTT assay, Ocimum americanum L., T47D, LC50.                               

 

 

Penulis : SESILIA ANDRIANI K, MSI., APT. [PDF File] didownload : 31 x

Cytotoxicity Test of Ocimum americanum L Leaves Extract Using Brine Shrimp Lethality Bioassay (BSLB)
Abstrak

An extraction of Ocimum americanum L. leaves have been conducted by maceration using n-hexane, ethyl acetate, ad methanol solvent. The purpose of this experiment is to detect the cytotoxic effect of the Ocimum americanum L. leaves extract in three different solvent using Brine Shrimp Lethality Bioassay (BSLB) method by determining the LC50 values. Data is analyzed using Linear Regression Analysis. Result of the research indicated that the LC50 values for Ocimum americanum L. leaves extract in n-hexane solvent is 174.748 ppm, in ethyl acetate solvent is 505.442 ppm, and in methanol solvent is 51.193 ppm. The conclusion of this research is that all Ocimum americanum L. leaves extracts have cytotoxic potential, but the extract in methanol solvent has the highest potential. This experiment is usually used as an introduction to screen for an anticancer compound.

Keywords: cytotoxicity, Ocimum americanum L., extract, Brine Shrimp Lethality Bioassay, LC50

Penulis : SESILIA ANDRIANI K, MSI., APT. [PDF File] didownload : 33 x

Integritas Negara Kesatuan Republik Indonesia Dihadapkan Dengan Otonomi Daerah yang Seluas Luasnya
Abstrak

The multi dimensional crisis are still happening in Indonesia have created much problems which have significant impacts towards the way of living. Those crisis not only have effected the political, economical, and social instability, but also problems in the regional development sector. The formulations of ordinance number 22 year 1999 regarding the regional government and its replacement which is the ordinance number 32 year 2004 regarding the regional government have given major changes in the regional government system. However the accordance with this changes, there are many different perception regarding the government's policy.

Keyword : power distribution, state form, state functions, decentralization, federalism, and regional self governing.

 

Penulis : EDIE TOET HENDRATNO , Prof. Dr. S.H., M.Si [PDF File] didownload : 67 x

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