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Ekstrak kulit buah manggis kaya akan antioksidan. α-Mangostin adalah komponen dengan efek antioksidan paling tinggi dalam kulit buah manggis. Larutan oral yang mengandung ekstrak kulit buah manggis perlu diuji penetapan kadar untuk pengujian mutunya. Penentuan kadar analit dalam sampel dengan matriks yang sangat kompleks dan jumlah analit sangat kecil, seperti α-mangostin dalam larutan oral, diperlukan metode yang selektif dan sensitif, yaitu kromatografi cair kinerja tinggi (KCKT). Pada penelitian ini dilakukan penetapan kadar α-mangostin dengan sistem KCKT fase balik dengan menggunakan fase diam oktadesilsilan (C18), fase gerak metanol-air (90:10), laju alir 1,0 mL/menit, dan detektor UV pada 316 nm. Waktu retensi α-mangostin adalah 9,622 menit. Puncak α-mangostin terpisah baik dengan resolusi sebesar 1,725. Linearitas metode berada pada rentang 1,67-5,01 bpj dengan koefisien korelasi 0,9986. Nilai simpangan baku relatif (SBR) sebesar 1,30%, perolehan kembali berada pada rentang 95,80-100,76% dengan nilai t hitungKata kunci: validasi metode, KCKT, α-mangostin, larutan oral, Garcinia mangostana L.

URL: 104-1606-1-PB_Alchemy.pdf

Customer loyalty is ‘suspected’not been able to optimization repetition of transactions, customer recommendation and durability with the establishment relationship quality of the trust, customer satisfaction and commitment. Therefore, research conducted on Bank CIMB Niaga aims to determine the extent of the trust, and commitment to customer satisfaction can increase X-tra and TabunganKU savings customer loyalty. This research is verification and the method of research is explanatory survey method, the sample is 160 customer X-tra and tabunganKU savings in the branch office Bank CIMB Niaga Bintaro. The analytical method used is structural equation model. The results showed loyalty can be achieved with relationship quality for customers through the establishment of trust, and commitment to customer satisfaction, which all three have a positive influence. Therefore, the management of Bank CIMB Niaga need to improve their ability in trust, satisfactionand commitment with the bank's customers to become increasingly favored customers.

Kata Kunci: lembaga keuangan, pelanggan, loyalitas, model persamaan struktural

Banana peel is one of biological material that has been used as biosorbent. Uli banana (Musa x paradisiaca AAB) peel is fairly abundant food waste. The aims of this study is to determine the adsorption capacity of uli bananas peel powder as biosorbent of lead solution. Uli banana peel was dried then grounded to powder, sieved until the particle size is less than 125 micron. The effect of pH and lead concentration was investigated. The optimum pH for removing the lead in aqueous solution is pH 4. The metal uptake capacity at pH 2, 4, 6, 8 are 0.5; 1.7; 1.5, 0.7 mg/g and at the lead concentration of 7.5, 10, 12.5, 15, 17.5, 20, 22.5 and 25 ppm are 1.1, 1.7, 1.7, 1.8, 1.9, 1.8, 2.0, 2.2 mg/g consecutively.

Keywords: biosorbent, banana peel, lead, uli banana

Nowadays the exploration of anti-hyperuricemia herbs becomes more interesting, but making an animal model of hyperuricemia is still facing a problem due to a different uric acid metabolism between mice and human. The aim of this study was to investigate the effects of essence of chicken (EC) and urease inhibitor, oxonic acid potassium salt (PO) used singly or in combination on the concentration of serum uric acid in mice, to determine the optimal procedure, time of blood withdrawal and induction period and to evaluate the feasibility of this method to establish a mouse model of hyperuricemia. Determination of blood withdrawal time was as follows: DDY mice was given PO 250 mg/kgBW intra peritoneally and the blood was collected per hour to measure the plasma uric acid concentration. Determination of inductor combination and period of induction time were conducted by dividing mice into 6 groups: normal, PO 1 day, PO 3 days, PO and EC 1 day, PO and EC 3 days and EC 3 day and PO only on the third day. On the third day, the blood was collected and plasma uric acid was reacted with EHSPT (N-Ethyl-N-(2-hydroxy-3-Sulfopropil) m-Toluidine) and 4-AAP(4-Aminoantipyrine). The absorbance of color formation were measured by using spectrophotometer at 546 nm. The results showed that plasma uric acid was the highest at 2 hours after OA injection. The administration of both PO and EC could raise the uric acid compared with singly OA. Administration of EC and PO combination each day for 3 days’ consecutively could increase plasma uric acid in mice. In conclusion, the administration of chicken essence (EC) with oxonic acid potassium salt (PO) for 3 days significantly increased the plasma uric acid. Thus, this procedure could be used as a suitable method to establish a mouse model of hyperuricemia.

Keywords: hyperuricemia model, potassium oxonic acid, essence of chicken.

Bonggol nanas (Ananas comosus (L.). Merr) mengandung enzim bromelain dengan kadar tertinggi dibandingkan bagian nanas lainnya. Salah satu fungsi enzim bromelain adalah sebagai antimikroba. Ekstrak bonggol nanas dibuat dalam bentuk nanopartikel dengan menggunakan kitosan kemudian dikeringkan dengan metode freeze drying. Serbuk kering ekstrak ditentukan Konsentrasi Hambat Minimum (KHM) terhadap Staphylococcus aureus. Nanopartikel ekstrak kering dilakukan uji ukuran partikel, zeta potensial, dan morfologi partikel. Nanopartikel ekstrak kemudian diformulasikan ke dalam bentuk sediaan gel. Tiap formula dilakukan uji mutu fisik antara lain organoleptik, homogenitas, viskositas dan sifat alir dan uji mutu kimia (pH). Hasil penelitian menunjukkan nanopartikel ekstrak memiliki ukuran partikel 60,8 nm dan bentuk partikel kering sferis. Ekstrak bonggol nanas memiliki KHM pada konsentrasi 1,25%. Gel formula IV menunjukkan DDH tertinggi yaitu 62,5 mm dan memiliki viskositas dan pH yang stabil. Dengan demikian pembuatan nanopartikel pada ekstrak bonggol nanas dapat meningkatkan aktivitas antimikroba dalam sediaan gel untuk penggunaan secara topikal

Kata kunci: Bonggol nanas, nanopartikel, kitosan, antimikroba