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Publikasi Penelitian Dosen

Analysis on Regional Autonomy associated with the Legislative Process in Perspective of Sociology of Law
Abstrak
Penulis : EDIE TOET HENDRATNO , Dr., S.H., M.Si [PDF File] didownload : 2 x

In Vitro and In Vivo Antiplasmodial Activities of Garcinia Parvifolia (MIQ)MIQ Leaves From Indonesia
Abstrak

In Vitro and In Vivo Antiplasmodial Activities of Garcinia Parvifolia (MIQ)MIQ Leaves From Indonesia

1 Syamsudin Abdilah, 2 Risma Marisi Tambunan, 3 Yunahara Farida,

1Ros Sumarny and 4 Rita Marleta Dewi

 1 Departement of Pharmacology, 2 Departement of Biology Pharmacy, 3 Departement of Chemical Pharmacy

Faculty of Pharmacy, Pancasila University, South Jakarta 12640, Indonesia

4 Research and Development Center for Pharmacy and Biomedicine, Jakarta, Indonesia

 

Abstract: The objective of this research is to determine in vitro and in vivo antiplasmodial activities of G. parvifolia (Miq)Miq leaves. Methods: in vitro antiplasmodial test by microscopic and Malaria SYBR Green I-based Fluoresence (MSF) assay is indicated by the value of IC50; meanwhile, in vivo antiplasmodial assay used suppression method for 4 hours in P. berghei-infected mice. Leaves of G. parvifolia (Miq)Miq were extracted by means of chloroform and methanol solvent, and then the anti-plasmodium activity is tested in vitro by means of microscopic method and Malaria SYBR Green I-based Fluoresence (MSF) methods. Results: In microscopic method, the  value of IC50 was obtained from chloroform  extract i.e.33,17 µg/mL in D6 strain and 0,55 µg/mL in W2 strain. In Malaria SYBR Green I-based Fluoresence (MSF) method, the IC50 value was obtained from methanol extract i.e. 48,00 µg/mL in D6 strain and 56,37 µg/mL in W2 strain. In vivo assay found that chloroform extract had an  ED50 value of 156,22 mg/kg BW, stronger than that of methanol extract with an ED50 value of 412,92 mg/kg BW. Conclusions: The study concludes that chloroform and methanol extract of G. parvifolia (Miq)Miq leaves have anti-plasmodum activity against P. falcifarum culture of D6 strain, W2 strain on microscopic and  Malaria SYBR Green I-based Fluoresence (MSF) methods just like in vivo assay in P. berghei-infected mice does. The assay found that chloroform extract has stronger anti-plasmodial activity than methanol extract.

 

Keywords. G. parvifolia (Miq)Miq leaves, in-vivo antiplasmodial activity, in-vitro antiplasmodial activity

 

Link: http://issuu.com/iosrjournals/docs/f09652832

Penulis : ROS SUMARNY , Dr. [PDF File] didownload : 1 x

ANTIOXIDANT STUDY OF COSOLVENT SOLUTION OF MANGOSTEEN (Garcinia mangostana L.) RIND EXTRACT IN RATS BY USING MDA PARAMETER
Abstrak

ANTIOXIDANT STUDY OF COSOLVENT SOLUTION OF MANGOSTEEN (Garcinia mangostana L.) RIND EXTRACT IN RATS BY USING MDA PARAMETER

 

Ros Sumarny, Liliek Nurhidayati, Yati Sumiyati, Fransiska Diana Santi

Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia

Email: rosaries15@yahoo.com

 

 

ABSTRACT

 

Garcinia mangostana Linn (G. mangostana) rinds is a natural product that high considerable attention as antioxidant. The aim of this study was to investigate antioxidant effect of a-mangosteen from G. mangostana which prepared as cosolvent solution and ethanolic extract suspension. This was experimental study where antioxidant effect assessed by using Malondialdehyde (MDA) parameter. Twenty five rats were devided into 5 groups: negative control (I); positive controls (II); cosolvent solution (III); extract suspension (IV); and commercial extract® suspension (V) of 33,1 mg/kg BW a-mangosteen (G. mangostana). Rats were induced by carbon tetrachloride (CCl4) to produce trichlorometylperoxyl, a free radical which react with antioxidant. MDA concentration was analyzed by using Thiobarbituric acid method. Kruskall Wallis test was used to see the differences between groups and Mann Whitney test was used to see the differences between two groups. MDA plasma concentration are 1,0±0,19; 0,3±0,05; 0,4±0,04; 0,6±0,04 and 0,5±0,00 nmol/μL for group I, II, III, IV, and V respectively. There are significant different between groups III with groups IV and V (p<0,05) whereas cosolvent solution has lower MDA concentration compare to both extracts solution. Potential inhibition for MDA formation of cosolvent solution is 60%. In conclusion, cosolvent solution has higher antioxidant effect than extracts suspension.

 

Keywords: α-mangostin, Garcinia mangostana L, antioxidant, MDA, SOD

Penulis : ROS SUMARNY , Dr. [PDF File] didownload : 2 x

HPLC Method Precision to Assay of α-Mangostin in Mangosteen (Garcinia mangostana L.) Fruit Rind Extract Formulated in Oral Solution
Abstrak

HPLC Method Precision to Assay of α-Mangostin in Mangosteen

(Garcinia mangostana L.) Fruit Rind Extract Formulated in Oral Solution

 

Liliek Nurhidayati, liliek_nurhidayati@yahoo.com, 08129602984; Siti Sofiah,ssofiah19@gmail.com, 02170244949; Ros Sumarny, rosaries15@yahoo.com,081318463091; Kevin Caesar, akevincaesar@hotmail.com, 081808153131

Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia

Abstract

 Mangosteen fruit rind is rich in antioxidant compounds especially α-mangostin. The developed formulation of oral solution that contains mangosteen fruit rind extract needs an assay method for quality testing. The α-mangostin compound can be used as chemical marker. To determine a very low concentration of analyte in sample with very complex matrix, such as in oral solution, it needs a selective and sensitive method. In this study, α-mangostin assay was performed by reverse phase-HPLC system using octadecylsilane (C18) stationary phase with methanol-water (90:10) as mobile phase, flow rate of 1.0 mL/min, and UV detector at 316 nm.  The retention time of α-mangostin was 9.622 minutes. This method met the precision requirements with the relative standard deviation  of 1.30 %.

Keywords: α-mangostin, Garcinia mangostana L, oral solution, HPLC, precision 

http://icpp2014.com

 

 

Penulis : ROS SUMARNY , Dr. [PDF File] didownload : 1 x

PENGARUH PEMBERIAN SEDIAAN MIKROMINERAL PADA FERTILITAS MENCIT BETINA GALUR DDY
Abstrak

PENGARUH PEMBERIAN SEDIAAN MIKROMINERAL PADA FERTILITAS MENCIT BETINA GALUR DDY

(Effect of Microminerals against Fertility Mice Female DDY Strain)

Ros Sumarny 1 & Pudjiastuti 1

1 Fakultas Farmasi Universitas Pancasila Jakarta

email: rosaries15@yahoo.com

ABSTRACT

 

Microminerals were needed by the body in very small amounts in which they have important physiological roles in the body including the fertilization of living things. This study aimed to observe the dose and period of administration of the preparation of microminerals in order to improve the fertilization in female mice of DDY strain. The study was conducted on 60 female mice of DDY strain with five different concentration of microminerals namely 1.5 ; 3.0 ; 6.0 ; 12 and 24 % (v/v). The study was continued using three different period of administration namely 10 days before the mating, 18 days after the mating and 28 days (10 days followed by 18 days after mating) in which the method used was designed in the manner of bigamy ie 1 male mouse caged with 2 female mice. The preparation was given every day during three different period of the observation. The indicator of fertilization was macroscopically observed by counting the number of fetus in the uterus of female mice on 19th day after the appearance of a vaginal plug. As conclusion, the greatest number of fetus was obtained from the administration of the preparation with concentration of 6 % that was given for 10 days before the mating.

 

Keywords: microminerals, fertilization, female mice

Penulis : ROS SUMARNY , Dr. [PDF File] didownload : 2 x

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