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Publikasi Penelitian Dosen

Analisis Tingkat Kapabilitas dan Level Sigma Ketepatan Waktu Perjalanan KRL Commuter Liner Bekasi pada Penerapan Pola Singe Operation di PT. KAI Commuter Jabodetabek
Abstrak

PT KAI Commuter Jabodetabek adalah salah satu anak perusahaan PT KERETA API (Persero) yang menyelenggarakan pengusahaan pelayanan jasa angkutan kereta api komuter dengan menggunakan sarana Kereta Rel Listrik di wilayah Jabodetabek. Pada tanggal 2 Juli 2011, PT KAI Commuter Jabodetabek mulai memberlakukan pola operasi Single Operation. Single operation merupakan aturan yang mengharuskan seluruh rangkaian KRL Jabodetabek, khususnya KRL AC berhenti di setiap stasiun kereta. Dengan pola Single Operation ini yang menjadi kendala utama PT KAI Commuter Jabodetabek adalah adanya keluhan penumpang mengenai jadwal KRL Commuter Line yang datang tidak tepat waktu yang mengakibatkan perjalanan KRL Commuter Line menjadi lebih lama dari yang dijadwalkan. Untuk meningkatkan kualitas pelayanan PT KAI Commuter Jabodetabek dalam hal ketepatan waktu kedatangan KRL Commuter Line di stasiun tujuan, maka diperlukan analisis tingkat kapabilitas dan level sigma dalam menentukan tingkat kualitas dari performa perjalanan KRL Commuter Line, khususnya pada saat jam sibuk di pagi dan sore hari. Melalui analisis tingkat kapabilitas dan level sigma ini dapat diketahui sampai pada level sigma berapa tingkat proses yang dijalani PT KAI Commuter Jabodetabek saat ini. Pada penelitian ini, variabel-variabel yang diteliti adalah waktu kedatangan KRL Commuter Line Bekasi Nomor 5207 dari Bekasi tujuan Jakarta Kota, jadwal datang di stasiun Jakarta Kota pukul 07.46 wib dan waktu kedatangan KRL Commuter Line Bekasi Nomor 5238 dari Jakarta Kota tujuan Bekasi, jadwal datang di stasiun Bekasi pukul 18.06 wib. Dari hasil perhitungan kapabilitas proses dari waktu keterlambatan kedatangan KRL Commuter Line Bekasi Nomor 5207 di stasiun Jakarta Kota didapat hasil Potencial Capability (Cpu) sebesar -0.173 dan nilai sigma -0.42 sigma dengan PPM 662800 ppm. Hasil perhitungan kapabilitas proses dari waktu keterlambatan kedatangan KRL Commuter Line Bekasi Nomor 5238 di stasiun Bekasi didapat hasil Potencial Capability (Cpu) sebesar -0.266 dan nilai sigma -0.79 sigma dengan PPM 785200 ppm. Berdasarkan hasil evaluasi yang dilakukan dengan diagram sebab akibat dapat diketahui faktor-faktor penyebab keterlambatan kedatangan KRL Commuter Line Bekasi yaitu antrian KRL Jabodetabek dengan KA jarak jauh,perhitungan Gapeka belum akurat,rangkaian KRL Commuter Line  sering mengalami gangguan teknis, rangkaian KRL Ekonomi sering mogok, mesin persinyalan dan wesel sering mengalami gangguan,awak KRL dan petugas perjalanan datang terlambat.

Kata kunci : Kapabilitas Proses, Level Sigma, Keterlambatan Kedatangan KRL

 

Penulis : NUR YULIANTI HIDAYAH, ST.MT [PDF File] didownload : 3 x

Thiolated hydroxyethyl cellulose: Design and in vitro evaluation of mucoadhesive and permeation enhancing nanoparticles
Abstrak

Within this study, HEC-cysteamine nanoparticles with free thiol groups in the range of 117–1548 l mol/g
were designed and characterized. Nanoparticles were generated via ionic gelation of the cationic polymer
with tripolyphosphate (TPP) follow ed by covalent crosslinking via disulfide bond formation using H 2O2 as
oxidant. The mean diameter of the particles was in the range of 270–360 nm, and zeta potential was
determined to be +4 to +10 mV. Nanopar ticles were evaluated in terms of mucoadhesive, permeation
enhancing, and biocompatible properties as well as biodegradability. The particles remained attached
to porcine intestinal mucosa up to 70% after 3 h of incubation. The more nanoparticles were oxidized;
however, the less were their mucoadhesive properties. Nanoparticles applied in a concentration of
0.5% (m/v) with the highest content of free thiol groups improved the transport of fluorescein isothiocy-anate dextran 4 (FD4) across Caco-2 cell monolayer 3.94-fold in comparison with control (buffer). In
addition, the transport of FD4 was even 1.84-fold enhanced in the presence of 0.5% (m/v) nanoparticles
with the lowest free thiol group content. The higher the disulfide bond content within nanop articles was,
to a lower degree nanoparticles were hydrolyzed by cellulase. None of these nanoparticles showed pro-nounced cytotoxicity. According ly, HEC-cysteamine could be a promising excipient for nanoparticulate
delivery systems for poorly absorbed drugs.

Penulis : DENI RAHMAT, Dr. rer. nat. [PDF File] didownload : 5 x

HEC-cysteamine particles: influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties
Abstrak

Within this study, the influence of particle size and zeta potential of hydroxyethyl cellulose–cysteamine particles on
permeation enhancing properties was investigated. Particles were prepared by four different methods namely ionic
gelation, spray drying, air jet milling and grinding. Particles prepared by grinding were additionally air jet milled. All
particles were characterized in terms of particle size and zeta potential. The transport of fluorescein isothiocyanate-dextran 4 (FD4) across Caco-2 cell monolayers in the presence of these particles and the decrease in transepithelial
electrical resistance (TEER) was evaluated. The cytotoxic effect of the particles was investigated using resazurin assay.
Nanoparticles displaying a zeta potential of 3.3 ± 1.3 mV showed the highest enhancement of FD4 transport among
all particles with a 5.83-fold improvement compared to buffer only. Due to the larger particle size, particles generated
by grinding exhibited a lower capability in opening of tight junctions compared to smaller particles generated by air
jet milling. In addition, the results of the transport studies were supported by the decrease in the TEER. All particle
formulations tested were comparatively non-cytotoxic. Accordingly, the zeta potential and particle size showed
a significant impact on the opening of tight junctions and hence could play an important role in the design of
hydroxyethyl cellulose (HEC)-cysteamine-based nano- and micro-particles as drug delivery systems.

Penulis : DENI RAHMAT, Dr. rer. nat. [PDF File] didownload : 4 x

Design and synthesis of a novel cationic thiolated polymer
Abstrak

The purpose of this study was to design and characterize a novel cationic thiolated polymer. In this regard a
hydroxyethylcellulose-cysteamine conjugate (HEC-cysteamine) was synthesized. Oxidative ring opening
with periodate and reductive amination with cysteamine were performed in order to immobilize free
thiol groups to HEC. The resulting HEC-cysteamine displayed 2035 ± 162  mol immobilized free thiol
groups and 185 ± 64 mol disulfide bonds per gram of polymer being soluble in both acidic and basic
conditions. Unlike the unmodified HEC, in case of HEC-cysteamine, a three-fold increase in the viscosity
was observed when equal volumes of the polymer were mixed with mucin solution. Tablets based on
HEC-cysteamine remained attached on freshly excised porcine mucosa for 80 h and displayed increased
disintegration time of 2 h. Swelling behavior of HEC-cysteamine tablets in 0.1 M phosphate buffer pH 6.8
indicated swelling ratio of 19 within 8 h. In contrast, tablets comprising unmodified HEC detached from
the mucosa within few seconds and immediately disintegrated. In addition, they did not exhibit swelling
behavior. The transport of rhodamine 123 across freshly excised rat intestine enhanced by a value of
approximately 1.6-fold (p -value = 0.0024) in the presence of 0.5% (m/v) HEC-cysteamine as compared to
buffer control. Result from cytotoxicity test of HEC-cysteamine applied to Caco-2 cells in concentration
of 0.5% (m/v) revealed 82.4 ± 4.60% cell viability. According to these results, HEC-cysteamine seems to be
a promising polymer for various pharmaceutical applications especially for intestinal drug delivery

Penulis : DENI RAHMAT, Dr. rer. nat. [PDF File] didownload : 5 x

Evaluasi Penggunaan Antibiotik di Bangsal HCU dan IVU Rumah Sakit Kanker Dharmais Periode Februari-Maret 2012
Abstrak

Evaluation of Antibiotic Usage in HCU and  ICU Wards in “Dharmais” Cancer Hospital February to March 2012           

Yusi Anggriani1, Agusdini Banun2, Erliana1

1 Fakultas Farmasi Universitas Pancasila, 2Rumah Sakit Kanker Dharmais.

 

Abstrak: Penggunaan antibiotika yang tinggi dapat memicu penggunaan antibiotika yang tidak rasional. Penelitian bertujuan untuk mengevaluasi penggunaan antibiotika secara kuantitatif dan kualitatif selama bulan Februari-Maret 2012. Pengambilan data dilakukan secara prospektif dengan mengambil data dari rekam medis dan pengamatan langsung pasien yang sedang dirawat. Parameter evaluasi kuantitatif menggunakan indikator WHO tentang evaluasi penggunaan antibiotika di rumah sakit dan Defined Daily Dose. Evaluasi kualitatif menggunakan kriteria Gyssens. Hasil studi menunjukkan, antibiotika paling banyak digunakan pada bulan Februari adalah seftriakson, yaitu 54,5 DDD/100 hari rawat di ruang HCU dan 52,5 DDD/100 hari rawat di ruang ICU. Penggunaan antibiotika terbanyak di bulan Maret adalah meropenem (Ruang HCU 36,0 DDD/100 dan ruang ICU 122,73 DDD/100 hari rawat). Penggunaan antibiotika kombinasi sebesar  32,9% di HCU sebesar dan pada pasien ICU 40%. Tes sensitivitas antibiotika hanya dilakukan pada 11,1% pasien yang menerima antibiotika. Tes kultur kuman hanya dilakukan pada 18 dari 153 pasien (11,8%). Pasien ADE (Antimicrobial Documented Empirical) sebanyak 98,7%, ADT (Antimicrobial Documented Therapy)  sebanyak 1,3% dan ADET (Antimicrobial Documented Empirical Therapy) sebanyak 8,6%. Kategori VI paling banyak ditemukan yaitu sebanyak 88,2%. Penggunaan antibiotika sesuai dengan formularium 93,9%. 

Kata kunci:  Evaluasi, antibiotika, ATC/DDD, pola kuman, kriteria Gyssens

                                                                                                                     

 

Penulis : YUSI ANGGRIANI , Dr, M.Kes, Apt. [PDF File] didownload : 4 x

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