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Hasil penelitian wajib disertai sosialisasi

Publikasi Penelitian Dosen

Lymphedema
Abstrak
Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 1 x

Lymphedema
Abstrak
Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 1 x

Ethanol extract of Annona squamosa L. improves the lipid profile in hyperlipidemia rats
Abstrak

Hepatoprotective Study of Cosolvent Solution 

From Mangosteen (GARCINIA MANGOSTANA L.) Rind in Rats  

ROS SUMARNY*, LILIEK NURHAYATI, YATI SUMIYATI, ASTRI YULIASTRI PERMANA  

Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia. 

 

Abstract:

Garcinia mangostana L. rind consist of -mangostin, an active compound that considerably can protect the liver -mangostin which prepared as cosolvent solution and ethanolic extract suspension. This was experimental study where hepatoprotective effect was assessed using Aspartate transminase (AST) and Alanine transminase (ALT). Twenty five rats were divided into 5 groups: negative (I) and positive controls (II); cosolvent (III), extract (IV) and commercial extract suspensions (V) of 33,1 mg/kg BW -mangostin. Rats were treated for 14 days, and then induced by carbon tetrachloride to produce trichlorometylperoxyl, a free radical which cause lipid peroxidation. AST and ALT levels were analyzed by using kinetic UV method. Kruskall Wallis and Mann Whitney test were used in statistical analysis. AST levels were 207.08±9.17; 111.98±29.90; 134.54±30.00; 128.10±21.84 and 138.84± 16.62 UI/L meanwhile ALT levels were 79.18±17.29; 28.02±5.17; 37.1±5.25; 46.34±13.19 and 34.5±4.09 UI/L for group I, II, III, IV, V respectively. There were no significant differences between groups II with group III, IV and V (p<0.05) for AST, meaning comparable ability to inhibit AST and ALT increment between positive control with cosolvent and extracts solution. There were no significant differences between group III with group IV and V (p>0.05) for ALT and AST, meaning cosolvent, extract and extract  has comparable ability to inhibit enzymes increment. 

Keywords: α-mangostin, Garcinia mangostana L, AST, ALT, hepatoprotective. 

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 2 x

PENGARUH ANTIBIOTIKA PROFILAKSIS TERHADAP KEJADIAN INFEKSI LUKA OPERASI
Abstrak

PENGARUH ANTIBIOTIKA PROFILAKSIS TERHADAP KEJADIAN

INFEKSI LUKA OPERASI 

Oktaviana Zunnita,  Ros Sumarny, , July Kumal

 

ABSTRAK

Antibiotik profilaksis  adalah antibiotik  yang diberikan pada pasien yang akan 

menjalani pembedahan untuk mencegah terjadinya infeksi akibat tindakan operasi.

Antibiotik profilaksis diberikan secara intravena agar dicapai konsentrasi maksimum di

serum/jaringan pada saat operasi. Pemilihan antibiotika profilaksis yang sesuai pada

tindakan pembedahan sangat menentukan keberhasilan dalam mencegah terjadinya

infeksi luka operasi. Penelitian ini bertujuan untuk mengetahui besarnya angka kejadian

infeksi luka operasi dan mengevaluasi penggunaan antibiotika profilaksis dalam

pencegahan infeksi luka operasi di rumah sakit Premier Bintaro, Kota Tanggerang. Jenis

penelitian ini adalah observasional dengan rancangan studi deskriptif analitik melalui

penelusuran data yang dilakukan secara retrospektif pada pasien yang menjalani

pembedahan di ruang operasi. Analisa dan evaluasi data berupa deskripsi pola

penggunaan antibiotika profilaksis dan angka kejadian infeksi luka operasi serta

hubungan antara penggunaan antibiotika profilaksis dengan kejadian infeksi luka operasi.

Hasil yang diperoleh dalam penelitian ini menunjukan bahwa angka kejadian infeksi luka

operasi pada tindakan pembedahan sebanyak 7 kasus (1,97%) dari jumlah total 355 kasus

bedah pada periode penelitian. Antibiotika profilaksis yang paling banyak digunakan

adalah sefalosporin generasi III (66,2%). Hasil analisa dengan Fisher exact menunjukkan

bahwa sifat operasi, jenis antibiotika dan waktu pemberian antibiotika mempunyai

hubungan bermakna dengan kejadian ILO (p <0,05). Dari penelitian terlihat pula bahwa

semakin lama operasi berlangsung semakin tinggi risiko infeksi luka operasi. Antibiotik

sefalosporin generasi III terbanyak yang digunakan adalah ceftriaxone injeksi.

Kata kunci: Antibiotika profilaksis, sefalosporin, luka operasi 

 

 

 

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 1 x

Ethanol extract of Annona squamosa L. improves the lipid profile in hyperlipidemia rats
Abstrak

PROCEEDINGS OF THE 17 ASIAN CONFERENCE ON CLINICAL PHARMACY (ACCP 2017), 28–30 JULY 2017, YOGYAKARTA, INDONESIA

Ethanol extract of Annona squamosa L. improves the lipid profile in hyperlipidemia rats

R. Sumarny, Y. Sumiyati & D. Maulina

Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia 

 

Abstract:

Dyslipidemia is an important factor of cardiovascular disease. Sugar apple (Annona squamosa L.) fruit is empirically used to decrease blood lipid. The aim of this study was to investigate the effect of  the ethanol extract from sugar apple peel on lipid profile. Sprague-Dawley rat were given high-cholesterol food for 14 days. A total of 30 rats  were  divided into six groups, namely normal (I), negative (II) and positive/simvastatin control (III) and test groups, including extract doses of 125 (IV), 250 (V) and 500 mg/kg (VI). After 2 weeks, total cholesterol and triglyceride levels were decresed by 14.43%, 38.26%, 48.95% and 28.10%, 57.12%, 65.22%, whereas HDL-cholesterol were increased by 21.19%, 36.57%, 40.30% for group IV, V and VI, respectively. There was no significant difference in total cholesterol and HDL cholesterol parameters between groups III and VI. The study showed that sugar apple peel can improve the lipid profile by lowering total cholesterol and triglyceride levels and increasing HDL cholesterol levels.

 

 

Penulis : ROS SUMARNY , Prof. Dr., MS, Apt [PDF File] didownload : 1 x

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